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Jiaogulan(Gynostemma pentaphyllum)
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Jiaogulan/Drug Interactions:- Anticancer agentsAnticancer agents: Based on in vitro studies, gypenosides extracted from Gynostemma pentaphyllum may have anticancer effects, such as decreasing cancer cell viability, arresting the cell cycle, and inducing apoptosis (4; 6; 7; 8).
- AntilipemicsAntilipemics: Based on a clinical study of patients with nonalcoholic fatty liver disease, Gynostemma pentaphyllum may decrease serum triglyceride levels (4). Based on an in vitro study, Gynostemma pentaphyllum may activate liver X receptors, which play an important role in cholesterol homeostasis by serving as regulatory sensors of cholesterol levels in tissues (3).
- Anti-inflammatoriesAnti-inflammatories: Based on an in vitro study, Gynostemma pentaphyllum may inhibit nuclear factor-kappaB activation, an important inflammatory factor (2).
- Anticoagulants and antiplateletsAnticoagulants and antiplatelets: Based on an in vitro study Gynostemma pentaphyllum may significantly inhibit the platelet aggregation, accelerate disaggregation, and inhibit thrombosis (p<0.05). However, based on another in vitro study, Gynostemma pentaphyllum Makino may contain a platelet aggregation factor (1).
- Hepatotoxic agentsHepatotoxic agents: Based on a clinical study of patients with nonalcoholic fatty liver disease, Gynostemma pentaphyllum may decrease alanine aminotransferase, alkaline phosphatase, or aspartate aminotransferase levels (4).
- Antidiabetic agentsAntidiabetic agents: Based on a clinical study of patients with nonalcoholic fatty liver disease, Gynostemma pentaphyllum may decrease insulin levels and insulin index scores (4).
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Jiaogulan/Herb/Supplement Interactions: - Anticancer agentsAnticancer agents: Based on in vitro studies, gypenosides extracted from Gynostemma pentaphyllum may have anticancer effects, such as decreasing cancer cell viability, arresting the cell cycle, and inducing apoptosis (9; 6; 7; 8).
- AntilipemicsAntilipemics: Based on a clinical study of patients with nonalcoholic fatty liver disease, Gynostemma pentaphyllum may decrease serum triglyceride levels (4). Based on an in vitro study, Gynostemma pentaphyllum may activate liver X receptors, which play an important role in cholesterol homeostasis by serving as regulatory sensors of cholesterol levels in tissues (3).
- Anti-inflammatoriesAnti-inflammatories: Based on an in vitro study, Gynostemma pentaphyllum may inhibit nuclear factor-kappaB activation, an important inflammatory factor (2).
- Anticoagulants and antiplateletsAnticoagulants and antiplatelets: Based on an in vitro study Gynostemma pentaphyllum may significantly inhibit the platelet aggregation, accelerate disaggregation, and inhibit thrombosis (p<0.05). However, based on another in vitro study, Gynostemma pentaphyllum Makino may contain a platelet aggregation factor (1).
- Hepatotoxic agentsHepatotoxic agents: Based on a clinical study of patients with nonalcoholic fatty liver disease, Gynostemma pentaphyllum may decrease alanine aminotransferase, alkaline phosphatase, or aspartate aminotransferase levels (4).
- Hypoglycemic/hyperglycemic agentsHypoglycemic/hyperglycemic agents: Based on a clinical study of patients with nonalcoholic fatty liver disease, Gynostemma pentaphyllum may decrease insulin levels (4).
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Jiaogulan/Food Interactions:- Insufficient available evidence.
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Jiaogulan/Lab Interactions:- Coagulation panelCoagulation panel: Based on an in vitro study Gynostemma pentaphyllum may significantly inhibit the platelet aggregation, accelerate disaggregation, and inhibit thrombosis (p<0.05). However, based on another in vitro study, Gynostemma pentaphyllum Makino may contain a platelet aggregation factor (1).
- Insulin levelsInsulin levels: Based on a clinical study of patients with nonalcoholic fatty liver disease, Gynostemma pentaphyllum may decrease insulin levels (4).
- Insulin resistance indexInsulin resistance index: Based on a clinical study of patients with nonalcoholic fatty liver disease, Gynostemma pentaphyllum may decrease insulin resistance index scores (4).
- Liver enzymesLiver enzymes: Based on a clinical study of patients with nonalcoholic fatty liver disease, Gynostemma pentaphyllum may decrease alanine aminotransferase, alkaline phosphatase, or aspartate aminotransferase levels (4).
- Lipid panelLipid panel: Based on a clinical study of patients with nonalcoholic fatty liver disease, Gynostemma pentaphyllum may decrease serum triglyceride levels (4). Based on an in vitro study, Gynostemma pentaphyllum may activate liver X receptors, which play an important role in cholesterol homeostasis by serving as regulatory sensors of cholesterol levels in tissues (3).
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Copyright © 2011 Natural Standard (www.naturalstandard.com)
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The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.
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