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Goji/Drug Interactions:- AntibioticsAntibiotics: Based on in vitro study, the root bark from Lycium chinense Miller may have strong antimicrobial activity against antibiotic-resistant bacterial strains, methicillin-resistant Staphylococcus aureus (MRSA) (32).
- Anticoagulants and antiplateletsAnticoagulants and antiplatelets: Based on a case report of a 61 year-old Chinese woman patient who was stabilized on warfarin, Lycium barbarum L. fruit may elevate international normalized ratio (INR) (71).
- Antidepressants, monoamine oxidase inhibitors (MAOIs)Antidepressants, monoamine oxidase inhibitors (MAOIs): Based on in vitro study, Lycium chinense may inhibit MAO-B (61).
- AntidiabeticsAntidiabetics: Based on animal study, Lycium barbarum may decrease plasma glucose and 30-minute postprandial glucose levels (16; 15; 20; 53).
- AntifungalsAntifungals: Based on in vitro study, an ethyl acetate extract of the root bark of Lycium chinense Miller may have an antifungal effect (30; 32).
- AntihypertensivesAntihypertensives: Lycium may have antihypertensive effects (17). Theoretically, combined use of Lycium with other agents that decrease blood pressure may increase the risk of hypotension.
- AntilipemicsAntilipemics: Based on animal study, Lycium barbarum may decrease plasma cholesterol and plasma triglycerides (16; 20).
- AntineoplasticsAntineoplastics: Based on in vitro and animal studies, Lycium barbarum may have antineoplastic activity (73; 21; 14; 74; 13; 12; 28).
- AntiviralsAntivirals: Based on in vitro study, Lycium fruit may have antiviral activity (75).
- Cardiovascular agentsCardiovascular agents: Based on in vitro research, Lycium barbarum may have cardioprotective activity (49).
- Cytochrome P450 metabolized agentsCytochrome P450 metabolized agents: Based on an in vitro assessment, a tea of L. Barbarum L. may weakly inhibit S-warfarin metabolism by CYP2C9 (71).
- HepatotoxinsHepatotoxins: Based on animal study, Lycium chinense Miller (Solanaceae) fruit may have hepatoprotective effects and decrease levels of serum aspartate and alanine aminotransferase (AST and ALT) and alkaline phosphatase (ALP) (51).
- Hormonal agentsHormonal agents: Based on in vitro study, Lycium barbarum may regulate and increase the secretion of male sexual hormones (3).
- ImmunosuppressantsImmunosuppressants: Based on animal study, Lycium may have immunostimulatory activity (76; 21; 22).
- Insulin preparationsInsulin preparations: Based on animal study, Lycium barbarum may significantly increase insulin sensitivity (16).
- InterleukinsInterleukins: Based on a before and after comparison trial in patients with advanced cancer, Lycium barbarum polysaccharides administered in conjunction with LAK/IL-2 may increase NK and LAK cell activity (77).
- Osteoporosis drugsOsteoporosis drugs: Based on laboratory study, a water extract of Lycium chinense may stimulate osteoblast proliferation and inhibit osteoclast formation (63).
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Goji/Herb/Supplement Interactions:- AntibacterialsAntibacterials: Based on in vitro study, the root bark from Lycium chinense Miller, may have strong antimicrobial activity against antibiotic-resistant bacterial strains, methicillin-resistant Staphylococcus aureus (MRSA) (32).
- Anticoagulants and antiplateletsAnticoagulants and antiplatelets: Based on a case report of a 61 year-old Chinese woman patient who was stabilized on warfarin, Lycium barbarum L. fruit may elevate international normalized ratio (INR) (71).
- Antidepressants, monoamine oxidase inhibitors (MAOIs)Antidepressants, monoamine oxidase inhibitors (MAOIs): Based on in vitro study, Lycium chinense may inhibit MAO-B (61).
- AntifungalsAntifungals: Based on in vitro study, an ethyl acetate extract of the root bark of Lycium chinense Miller may have an antifungal effect (30; 32).
- AntilipemicsAntilipemics: Based on animal study, Lycium barbarum may decrease plasma cholesterol and plasma triglycerides (16; 20).
- AntineoplasticsAntineoplastics: Based on in vitro and animal studies, Lycium barbarum may have antineoplastic activity (73; 21; 14; 74; 13; 12; 28).
- AntiviralsAntivirals: Based on in vitro study, Lycium fruit may have antiviral activity (75).
- Cardiovascular agentsCardiovascular agents: Based on in vitro research, Lycium barbarum may have cardioprotective activity (49).
- Cytochrome P450 metabolized herbs and supplementsCytochrome P450 metabolized herbs and supplements: Based on an in vitro assessment, a tea of L. Barbarum L. may weakly inhibit S-warfarin metabolism by CYP2C9 (71).
- Hepatotoxic herbsHepatotoxic herbs: Based on animal study, Lycium chinense Miller (Solanaceae) fruit may have hepatoprotective effects, and decrease levels of serum aspartate and alanine aminotransferase (AST and ALT) and alkaline phosphatase (ALP) (51).
- Hormonal herbs and supplementsHormonal herbs and supplements: Based on in vitro study, Lycium barbarum may regulate and increase the secretion of male sexual hormones (3).
- HypoglycemicsHypoglycemics: Based on animal study, Lycium barbarum may decrease plasma glucose and 30-minute postprandial glucose levels (16; 15; 20; 53).
- HypotensivesHypotensives: Lycium may have antihypertensive effects (17). Theoretically, combined use of Lycium with other herbs and supplements that decrease blood pressure may increase the risk of hypotension.
- ImmunostimulantsImmunostimulants: Based on animal study, Lycium may have immunostimulatory activity (76; 21; 22).
- IronIron: Based on animal study, Lycium barbarum polysaccharides (LBP-4) may increase the level of iron in muscle and bone (72).
- Osteoporosis agentsOsteoporosis agents: Based on laboratory study, a water extract of Lycium chinense may stimulate osteoblast proliferation and inhibit osteoclast formation (63).
- Vitamin CVitamin C: The fruit of Lycium barbarum L. contain 0.5% of a novel stable precursor of ascorbic acid, which could theoretically increase serum ascorbic acid levels (78; 79).
- ZeaxanthinZeaxanthin: Based on a study in healthy volunteers, consumption goji may increase plasma zeaxanthin levels (80).
- ZincZinc: Based on animal study, Lycium barbarum polysaccharides (LBP-4) may increase the level of zinc in muscle and bone (72).
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Goji/Food Interactions:- Iron-containing foodsIron-containing foods: When fed to weanling mice, Lycium barbarum polysaccharides(LBP-4) enhanced the content of zinc and iron in pygal muscles and femora and reduced their body weight (72).Theoretically, consumption of Goji polysaccharides could increase the level of zinc and iron in muscle and bone.
- Vitamin C-containing foodsVitamin C-containing foods: The fruit of Lycium barbarum L. contain 0.5% of a novel stable precursor of ascorbic acid, which could theoretically increase serum ascorbic acid levels (78; 79).
- Zinc-containing foodsZinc-containing foods: Based on animal study, Lycium barbarum polysaccharides (LBP-4) may increase the level of zinc in muscle and bone (72).
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Goji/Lab Interactions:- Antibodies (serum)Antibodies (serum): Based on animal study, Lycium may increase in serum IgA and IgG levels (76).
- Lipid panelLipid panel: Based on animal study, Lycium barbarum may decrease plasma cholesterol and plasma triglycerides (16; 20).
- INRINR: Based on a case report of a 61 year-old Chinese woman patient who was stabilized on warfarin, Lycium barbarum L. fruit may elevate international normalized ratio (INR) (71).
- InsulinInsulin: Based on animal study, Lycium barbarum may significantly increase insulin sensitivity (16).
- Liver panelLiver panel: Based on animal study, Lycium chinense Miller (Solanaceae) fruit may have hepatoprotective effects and decrease levels of serum aspartate and alanine aminotransferase (AST and ALT) and alkaline phosphatase (ALP) (51).
- Platelet countsPlatelet counts: Based on study in chemotherapy-induced myelosuppressive and irradiated mice, Lycium barbarum polysaccharide may enhance peripheral platelet counts (12; 66).
- Red blood cell countsRed blood cell counts: Based on study in chemotherapy-induced myelosuppressive and irradiated mice, Lycium barbarum polysaccharide may enhance peripheral red blood cell counts (12; 66).
- Serum ascorbic acid levelsSerum ascorbic acid levels: The fruit of Lycium barbarum L. contain 0.5% of a novel stable precursor of ascorbic acid, which could theoretically increase serum ascorbic acid levels (78; 79).
- Serum glucose levelsSerum glucose levels: Based on animal study, Lycium barbarum may decrease plasma glucose and 30-minute postprandial glucose levels (16; 15; 20; 53).
- Serum hormone levelsSerum hormone levels: Based on in vitro study, Lycium barbarum may regulate and increase secretion of male sexual hormones (3).
- Serum levels of cytochrome P450 metabolized agentsSerum levels of cytochrome P450 metabolized agents: Based on an in vitro assessment, a tea of Lycium Barbarum L. may weakly inhibit S-warfarin metabolism by CYP2C9 (71).
- T-cell countsT-cell counts: Based on animal study, Lycium barbarum polysaccharide may significantly increased the numbers of CD4(+) and CD8(+) T-cells (22).
- White blood cell countsWhite blood cell counts: Based on study in irradiated mice, intraperitoneal Lycium chinense root may increase leukocyte counts (66).
- Zeaxanthin levelsZeaxanthin levels: Based on a study in healthy volunteers, consumption goji may increase plasma zeaxanthin levels (80).
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Goji/Other Interactions:- Radiation therapyRadiation therapy: Based on an animal study, a combination of Lycium barbarum polysaccharide and radiation may have significant radiosensitizing effects (25).
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Copyright © 2011 Natural Standard (www.naturalstandard.com)
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The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.
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